The Psychedelic Revolution Is Coming. Psychiatry May Never Be the Same.

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  • Published May 9, 2021Updated May 12, 2021

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It’s been a long, strange trip in the four decades since Rick Doblin, a pioneering

psychedelics researcher dropped his first hit of acid in college and decide

to dedicate his life to the healing powers of mind-altering compounds.

pushing for the legalization of psychedelics at the federal level, though with

Even as anti-drug campaigns led to the criminalization of Ecstasy, LSD and

pushing for the legalization of psychedelics at the federal level, though with

magic mushrooms, and drove most researchers from the field, Dr. Doblin

continued his quixotic crusade with financial help from his parents.

Dr. Doblin’s quest to win mainstream acceptance of psychedelics took a

significant leap forward on Monday when the journal Nature Medicine 

published the results of his lab’s study on MDMA, the club drug popularly

known as Ecstasy and Molly. The study, the first Phase 3 clinical trial

conducted with psychedelic-assist

therapy found that MDMA paired with counseling brought marked relief to patients

with severe post-traumatic stress disorder.

The results, coming weeks after a New England Journal of Medicine study 

that highlighted the benefits of treating depression with psilocybin, the

the psychoactive ingredient in magic mushrooms has excited scientists,

psychotherapists and entrepreneurs in the rapidly expanding field of

psychedelic medicine. They say it is only a matter of time before the

Food and Drug Administration grants approval for psychoactive

compounds to be used therapeutically — for MDMA as soon as 2023,

followed by psilocybin a year or two later.

After decades of demonization and criminalization, psychedelic drugs are on

the cusp of entering mainstream psychiatry, with profound implications for the field that in recent decades has seen few pharmacological advancements for

the treatment of mental disorders and addiction. The need for new therapeutics

has gained greater urgency amid a national epidemic of opioid abuse and suicides.

pushing for the legalization of psychedelics at the federal level, though with

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“Some days I wake up and can’t believe

how far we’ve come,” said Dr. Doblin, 67, who now oversees the Multidisciplinary Association for Psychedelic Studies, multimillion-dollar research and advocacy empire that employs 130 neuroscientists, pharmacologists, and regulatory specialists working to lay the groundwork for the coming psychedelics revolution.

The nation’s top universities are racing to set up psychedelic research centers,

pushing for the legalization of psychedelics at the federal level, though 

and investors are pouring millions of dollars into a pack of start-ups. States and

cities across the country are beginning to loosen restrictions on drugs,

the first steps in what some hope will lead to the federal decriminalization of

psychedelics for therapeutic and even recreational use. Buy MDMA Ecstasy pills for sale Online

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“There’s been a sea change in attitudes about what not long ago was considered

pushing for the legalization of psychedelics at the federal level, though with

fringe science,” said Michael Pollan, whose best-selling book on psychedelics,

“How to Change Your Mind,” has helped destigmatize the drugs in the

three years since it was published. “Given the mental health crisis in this

country, there’s great curiosity and hope about psychedelics and a

recognition that we need new therapeutic tools.”

The question for many is how far — and how fast — the pendulum should swing.

existing prohibitions could prove risky, especially for those with severe psychiatric

Even researchers who champion psychedelic-assisted therapy say the drive to

existing prohibitions could prove risky, especially for those with severe psychiatric

existing prohibitions could prove risky, especially for those with severe psychiatric

commercialize the drugs, combined with a growing movement to liberalize

existing prohibitions could prove risky, especially for those with severe psychiatric

disorders, and derail the field’s slow, methodical return to mainstream acceptance.

existing prohibitions could prove risky, especially for those with severe psychiatric

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The psychedelic researcher Rick Doblin dropped his first hit of acid in college and decided to dedicate his life to the healing powers of mind-altering compounds. Now his research center, MAPS, has raised $44 million over the past two years.
The psychedelic researcher Rick Doblin dropped his first hit of acid in college and decided to dedicate his life to the healing powers of mind-altering compounds. Now his research center, MAPS, has raised $44 million over the past two years. Credit…Tony Luong for The New York Times

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That’s him on the cover: Dr. Doblin holding a September 1985 issue of The Miami Herald magazine.
That’s him on the cover: Dr. Doblin holding a September 1985 issue of The Miami Herald magazine.Credit…Gretchen Ertl for The New York Times

Dr. Doblin’s organization,

MAPS is largely focused on winning approval for

drug-assist therapies and promoting them around the globe, but it is also

pushing for the legalization of psychedelics at the federal level, though with

strict licensing requirements for adult recreational use.

Numerous studies have shown that classic psychedelics like LSD and psilocybin

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

are not addictive and cause no organ damage in even high doses. And contrary to popular lore,

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

trip lead to chromosome damage.

But most scientists agree that more research is needed on other possible

side effects — like how the drugs might affect those with cardiac problems.

And while the steady accumulation of encouraging data has softened the

skepticism of prominent scientists, some researchers warn against the headlong

embrace of psychedelics without stringent oversight. Although “bad trips”

are rare, a handful of anecdotal reports suggest that psychedelics can induce psychosis in those with underlying mental disorders. Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

Dr. Michael P. Bogenschutz, a professor of psychiatry

who runs the four-month-old

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

Center for Psychedelic Medicine at NYU Langone Health, said most of the clinical

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

studies to date had been conducted with relatively small numbers of people who

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

were carefully vetted to screen out those with schizophrenia and other serious mental problems.

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

That makes it hard to know whether there will be potential adverse

reactions if the drugs are taken by millions of people without any guidance or supervision. “I know it sounds silly but, Kids, don’t take these at home,” Dr. Bogenschutz said. “I would just encourage everyone to not get ahead of the data.”

Psychedelics are suddenly awash in money.

Dr. Doblin can remember when research funding was nearly impossible to come by. But MAPS is flush now, having raised $44 million over the past two years.

Johns Hopkins, Yale, the University of California, Berkeley, and Mount Sinai Hospital in New York are among the institutions that have recently established psychedelic research divisions or are planning to do so, with financing from private donors.

And scientists are conducting studies on whether psychedelics can be effective

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

in treating everything from depression, autism, and opioid addiction to

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anorexia and the anxieties experienced by the terminally ill.

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More than a dozen start-ups have jumped

into the fray, and the handful of companies

that have gone public are collectively valued at more than $2 billion. Field Trip Health, a two-year-old Canadian company that trades on the Canadian Stock Exchange and the OTC Markets Group, has raised $150 million to finance dozens of high-end ketamine clinics in Los Angeles, Chicago, Houston, and other cities across North America. Compass Pathways, a Nasdaq-listed health care company that has raised $240 million, is conducting 22 clinical trials across 10 countries of psilocybin therapy for treatment-resistant depression.

Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

Investors have been encouraged

by the changing politics, a shift inspired in part by the nation’s accelerating embrace of recreational marijuana and by public weariness over America’s endless war on drugs. Last year, Oregon became the first state to legalize the therapeutic use of psilocybin. DenverOakland, Calif., and Washington, D.C., have decriminalized the drug, and several states, including California, are mulling similar legislation. Though the drugs remain illegal under federal law, the Justice Department has so far taken a

hands-off approach to enforcement, similar to how it has handled recreational marijuana.

Even some Republicans, a group that has traditionally opposed the liberalization of drug laws, are starting to come around. Last month, the former Texas governor Rick Perry, citing the high rates of suicide among war veterans, called on his state’s legislators to support a Democratic-sponsored bill that would establish a psilocybin study for patients with PTSD.

“We’ve had 50 years of government propaganda around these substances, and

thanks to the research and a grass-roots movement, that narrative is

changing,” said Kevin Matthews, a psilocybin advocate who led Denver’s

successful ballot measure. Ecstasy does not leave holes in users’ brains, studies say, nor will a bad acid

Long before Nancy Reagan warned the nation to just say no to drugs and

President Richard Nixon supposedly pronounced Timothy Leary “the most dangerous man in America,” researchers like William A. Richards were using psychedelics to help alcoholics go dry and cancer patients cope with end-of-life anxiety.

But as the drugs left the lab in the 1960s and were embraced by the counterculture

movement, the country’s political establishment reacted with alarm.

By the time the Drug Enforcement Administration issued its emergency ban on MDMA in 1985, funding for psychedelic

research had largely disappeared. Buy MDMA Ecstasy pills for sale Online

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